A NEW P65 ISOFORM THAT BIND THE GLUCOCORTICOID HORMONE AND IS EXPRESSED IN INFLAMMATION LIVER DISEASES AND COVID-19

A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19

Abstract Inflammation is a physiological process whose deregulation causes some diseases including cancer.Nuclear Factor kB (NF-kB) is a family of ubiquitous and inducible transcription factors, in which the p65/p50 heterodimer is the most abundant complex, that play critical roles mainly in inflammation.Glucocorticoid Receptor (GR) is a ligand-act

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An unexpected, pH-sensitive step of the enterovirus D68 lifecycle

ABSTRACTEnterovirus D68 (EV-D68) contributes significantly to pathogen-induced respiratory illnesses and severe neurological disorders like acute flaccid myelitis.We lack EV-D68 preventive measures, and knowledge of its molecular and cellular biology is incomplete.Multiple studies have highlighted the role of membrane compartments and autophagy dur

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Identification and functional analysis of the S-layer protein SplA of Paenibacillus larvae, the causative agent of American Foulbrood of honey bees.

The gram-positive, spore-forming bacterium Paenibacillus larvae is the etiological agent of American Foulbrood (AFB), a globally occurring, deathly epizootic of honey bee brood.AFB outbreaks are predominantly caused by two genotypes of P.larvae, ERIC I and ERIC II, with P.larvae ERIC II being the more virulent genotype on larval level.Recently, com

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